The Molecular Architecture of Human Complement Component C6
نویسندگان
چکیده
منابع مشابه
Complement component C6 deficiency and susceptibility to Neisseria meningitidis infections.
May 2004, Vol. 94, No. 5 SAMJ Meningococcal disease remains one of the most serious bacterial infections in both Western and developing countries. Despite recent advances in treatment the mortality rate remains at about 12%. There is a group of South Africans who are particularly vulnerable to this disease. They are individuals with genetically determined deficiencies of individual terminal com...
متن کاملMolecular basis for complement component 6 (C6) deficiency in rats and mice.
Complement component C6 is a part of the lytic membrane attack complex formed during complement activation. Animal modeling to define the role of C5a vs. C5b-9 in human disease has used rodents deficient in C6, yet the molecular basis for the deficiencies has not been ascertained. Oligonucleotides derived from a 493 bp EST sequence of the rat C6 gene were used to isolate full-length transcripts...
متن کاملMolecular basis of polymorphisms of human complement component C3
C3 exhibits two common allotypic variants that may be separated by gel electrophoresis and are called C3 fast (C3 F) and C3 slow (C3 S). C3 F, the less common variant, occurs at appreciable frequencies only in Caucasoid populations (gene frequency = 0.20). An increased prevalence of the C3 F allele has been reported in patients with partial lipodystrophy, IgA nephropathy, and Indian childhood h...
متن کاملFirst Component of Human Complement
The active esterase hydrolyzed certain synthetic amino acid esters, among which N-acetyl-L-tyrosine ethyl ester was most susceptible (3-5). This substrate was hydrolyzedmaximally between pH 7.5 and 8.2 and at 41°C. The esterase was inhibited by a heat-labile factor in human serum which did not appear to be related to any of the known components of complement, and by certain sulfbydryl-containin...
متن کاملA Blood Coagulation Abnormality in Rabbits Deficient in the Sixth Component of Complement (c6) and Its Correction by Purified C6
Evidence for the involvement of the sixth component of complement (C6) in normal blood coagulation is provided by the description of a coagulation abnormality in rabbits with a genetic C6 deficiency and by its correction with highly purified preparations of C6. Whole blood clotting time in glass or plastic was prolonged and prothrombin consumption was decreased in blood from the deficient anima...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)71607-4